WHC is still in active development. Read this to understand our approach.
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isomerdesign

Clozapine

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Clozapine

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Clozapine

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Clozapine

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Data

InChI: InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

Synonyms: Clozapine,NCGC00022902-11, Clozapin,J60AR2IKIC,Opera_ID_482,HMS3266A10,LEX-123,NCGC00022902-13,Fazaclo ODT,Versacloz,LX 100-129,CLOZAPINE, 8-CHLORO-11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPINE,Lopac-C-6305,NCGC00022902-05,CAS-5786-21-0,Prestwick_693,W-801,HMS3371H05,UNII-J60AR2IKIC,Bio2_000790,NCGC00015254-31, 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine, 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine,NCGC00015254-11,KBioSS_000310,NCGC00015254-04,HSDB 6478, Clozapinum [INN-Latin],Fazaclo, Klozapol (TN),CLOZAPINE [WHO-DD],Bio1_001414,8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(Ciozapine), W-801,Tox21_500276,Clozapine for peak identification,CLOZARIL,ZINC19796155,Clozapinum [INN-Latin],MFCD00153785,SCHEMBL8397,CHEBI:92657,KBio2_000310,NCGC00022902-12,CHEBI:3766,8-Chloro-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]diazepine,KBioSS_000599,CLOZAPINE (TEVA) [VANDF],HF-1854,Clozapine - Bio-X,NCGC00022902-07,3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine,8-Chloro-11-(4-methylpiperazine-1-yl)-5H-dibenzo[b,e]-[1,4]diazepine,CLOZAPINE (MYLAN) [VANDF], 8-Chloro-11-(4-methyl)-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine,CLOZAPINE (VERSACLOZ) [VANDF],NCGC00015254-03,NCGC00015254-08,CLOZAPINE (UDL) [VANDF], Clopine (TN),Azaleptine,Spectrum4_000898,DSSTox_CID_2855,KS-1166,D-107,NCGC00260961-01, Leponex (TN), HF1854,NCGC00015254-06,AKOS026749900,REGID_for_CID_2818,6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0,3,8]pentadeca-1,3(8),4,6,10,12,14-heptaene,HF 1854,Clozapine (caraco),Clozapinum,CLOZAPINE [INN],Clozapin,Clozapine, European Pharmacopoeia (EP) Reference Standard, Clozapina,8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine,KBioGR_000310,W-105432,SPECTRUM1500685, Fazaclo ODT,NCGC00015254-07,H10436,CLOZAPINE [USAN],8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(Clopazine),KBio1_000343,NCGC00015254-02,CHEMBL42,Tox21_110113,HMS3260H14,Bio2_000310,NCGC00022902-08, Clozapine(tautomer), LX 100-129,SPBio_002340,NCGC00022902-10,1333667-72-3,SBI-0050264.P004, Froidir (TN),NCGC00015254-14,KBio2_003167,NCGC00015254-20,NCGC00015254-18,KBioGR_001336, HF-1854,Prestwick1_000350,BDBM50001884,SW220247-1, Clozapina [INN-Spanish],8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine,8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine( Clozepine ),MLS001077282, Fazaclo (TN),HMS3657E15,CLOZAPINE [USP-RS],HMS2089L13,Bio1_000436,MLS000028472,NCGC00015254-15,SR-01000000096-5,Tox21_110113_1,Clozapine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material,CLOZAPINE (CARACO) [VANDF],Iprox,Clozapine (Clozaril),HMS3678F09,Tocris-0444, Clozapine (JAN/USP/INN),CPD000058365, 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine,DSSTox_GSID_22855,KBio2_000599,NSC757429,BRN 0764984,Clozapine for peak identification, European Pharmacopoeia (EP) Reference Standard,clozapine,NCGC00022902-06,KBio3_000620,Clozaril (TN), Clorazil,Clozapine (ivax),EU-0100276,EN300-52510, Zaponex (TN), Leponex,AB00052158-13,NSC 757429,BC164328, Lepotex,Clozapine (teva),Bio1_000925,HMS1989P12,SR-01000000096,KBio3_002979,3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine,CLOZAPINE (FAZACLO) [VANDF],Clozapine, British Pharmacopoeia (BP) Reference Standard,CLOZAPINE [JAN],Prestwick0_000350,Clorazil,8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine,GTPL38, 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine,8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine (Clozapine),HMS3414F09,8-chloro-11-(4-methyl-piperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine,CLOZAPINE [EP MONOGRAPH],HMS3259J17,DB00363,EINECS 227-313-7,NCGC00015254-16,CLOZAPINE (IVAX) [VANDF],NSC-757429,Clozapine (udl),8-Chloro-11-(4-methyl)-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine,HMS2096E21,LP00276,Clozapine (mylan),AB00052158-14,Q221361,DivK1c_000343,Clozapine [USAN:USP:INN:BAN],SPBio_000798,CLOZAPINE RESOLUTION MIXTURE [USP-RS],BRD-K37289225-001-23-2,Clozapine (JAN/USP/INN),Clozapine, drug standard, 1.0 mg/mL in methanol,Clozapine, solid,Clozapine Resolution Mixture, United States Pharmacopeia (USP) Reference Standard,6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1,3(8),4,6,10,12,14-heptaene,Z754926488,HMS2235E19,NCGC00015254-13,HMS3402P12,NCGC00015254-10, 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine, LEX-123,6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,9,12,14-heptaene,DTXSID5022855,3-chloro-6-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine,NCGC00015254-17,SR-01000000096-2,5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-,CLOZAPINE [MART.],Leponex, CLOZARIL,BRD-K37289225-001-09-1,HMS3742K03,SMR000058365,L013417,BCP25196,5786-21-0,CLOZAPINE [USP MONOGRAPH],CLOZAPINE [ORANGE BOOK],SR-01000000096-4,5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-,Clozapine 1.0 mg/ml in Acetonitrile,NCGC00015254-05,Asaleptin, 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine,HMS501B05,Clozapine (versacloz),NINDS_000343,AB00052158_15,CLOZAPINE [HSDB],Clozapine (fazaclo),L000195,C 6305,AKOS005064444,SR-01000000096-8,KBio2_005446, Denzapine (TN),HY-14539,CLOZAPINE (CLOZARIL) [VANDF],CLOZAPINE [VANDF],DSSTox_RID_76759,BDBM22869,DB-053121,C06924,NCGC00015254-12,8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine,Pharmakon1600-01500685, Clozaril (TN),CCG-39881, Clozapinum,HMS2092I16,NCGC00015254-01,3-Hydroxy-2-phenyl-propionic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester, Clozapine [USAN:INN:BAN],(E)-8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine,CCRIS 9171,SDCCGSBI-0050264.P005,8-Chloro-11-(4-methyl-1-piperazinyl)-10H-dibenzo[b,e][1,4]diazepine,D00283,s2459,Clozapina,Clozapina [INN-Spanish],786C210,Spectrum3_001828,Spectrum_000139,Clozapine solution, Fazaclo,Clozapine, United States Pharmacopeia (USP) Reference Standard,KBio2_002878,AB00052158_16,SCHEMBL33323,KBio2_005735,HMS1791P12,NC00667,Clozapine resolution mixture,HMS1921C16,NCGC00022902-02,HMS3713E21, C 6305, KS-1166,NCGC00015254-09,NCGC00188978-01,ZINC3872123, Iprox,CLOZAPINE [MI],Lepotex,KBio3_000619,NCGC00022902-04,HMS1569E21,NCGC00022902-09,DTXSID401020663,Spectrum2_000919,8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine,HMS1361P12,CS-0644

Estimated data

Solubility: -3.537 (log(S) in mol/L prediction using SolTranNet)

Blood Brain Barrier Permeability: Yes (prediction using frontiersin.org)

Addictivity Prediction: 37.9% (prediction based on www.mdpi.com)

Similarities

The following is a set of comparisons to understand the properties of this compound. This is still higly experimental and is still under active development. Please refer to our series of blog posts to fully understand our approach and its limitations. This information is for informational purposes only and should not be construed as medical advice.