Zopiclone

eszopiclone

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zopiclone

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Zopiclone

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Zopiclone

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Eszopiclone

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Zopiclone

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Eszopiclone

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Eszopiclone

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Zopiclone

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Eszopiclone

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SMILES:CN1CCN(C(=O)OC2C3=C(N=CC=N3)C(=O)N2C2=NC=C(Cl)C=C2)CC1

InChI:InChI=1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3

InChI key:GBBSUAFBMRNDJC-UHFFFAOYSA-N

Sinónimos:

Zopiclone (JAN/INN), Rhovane, 4-Methyl-1-piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester, Imovance,NCGC00016108-06,NCGC00024993-04,Zileze 7.5,[8-(5-Chloropyridin-2-yl)-7-oxo-2,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-9-yl]4-methylpiperazine-1-carboxylate,compound 3 [PMID: 8863805], Zopinox (TN), Zopiclodura,CHEMBL135400, Zopiclon von ct, Limovan,(rs)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine-5-yl 4-methylpiperazine-1-carboxylate, RP 27267,MLS000083579,ZOPICLONE [JAN],Amovane, 4-Methyl-1-piperazinecarboxylic acid ester with 6-(5-chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo(3,4-b)pyrazin-5-one, RP 27 267, Italfarmaco brand of zopiclone,Opera_ID_1759, Novo-zopiclone, Zopiclone [BAN:INN:JAN], Zopiclone, Imovane, Zimovane, Lunesta,Zopiclone, European Pharmacopoeia (EP) Reference Standard,Zopiclone, British Pharmacopoeia (BP) Reference Standard,EU-0101270, [(7S)-6-(5-chloropyridin-2-yl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methylpiperazine-1-carboxylate, Optidorm, Zopicalma, Imovane,03A5ORL08Q, Imovane (TN),SBI-0051236.P002, Zorclone,Ximovan,VS-02685, [6-(5-chloropyridin-2-yl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methylpiperazine-1-carboxylate,imovane,HMS3713H22, Clonmel brand of zopiclone,BRD-A34309505-001-08-5, Z4900_SIGMA, Zimovane (TN),ZOPICLONE [EP IMPURITY],27267 R.P.,STK599439, Zopiclon TAD, Zopiclonum [INN-Latin], Siaten, Estorra (TN),SR-01000000090-4,4-Methyl-1-piperazinecarboxylic acid ester with 6-(5-chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo(3,4-b)pyrazin-5-one, Merck dura brand of zopiclone,6-(5-chloropyrid-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine,BCP9000663, Opus brand of zopiclone, Zileze,Amoban (TN), Zopiclona [INN-Spanish],HY-B0741,DB01198, Zopiclona, Nu-Zopiclone,BDBM50248251,ZOPICLONE [MART.],6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate, Aventis brand of zopiclone,(+-)-Zopiclone, (5S)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate, Zopiclone (TN), Zopiclon beta, Dolorgeit brand of zopiclone,RP 27267,6-(5-Chloro-2-pyridinyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methyl-1-piperazinecarboxylate, Zopiclon AbZ, 6-(5-chloropyrid-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine,NCGC00024993-03, Lunivia,1ST10124, Zopiclon AZU,NCGC00016108-05,4-Methyl-piperazine-1-carboxylic acid 6-(5-chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl ester, 1-Piperazinecarboxylic acid, 4-methyl-, (5S)-6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl ester, Ximovan, Eszopiclone [USAN:INN], Zopiclon Stada,Lopac0_001270, Zopi-Puren,SR-01000000090-6,ZOPICLONE [INN],1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl ester,MLS001304058,NCGC00016108-04,CCG-205343,BBL010797,UNII-03A5ORL08Q,Zopiclone 1.0 mg/ml in Acetonitrile,D01372,RP-27267,Zopiclone [BAN:INN:JAN],200Z802, 6-(5-Chloro-2-pyridinyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methyl-1-piperazinecarboxylate,Zimovane, TAD brand of zopiclone, Betapharm brand of zopiclone,HMS3267I08,6-(5-chloropyridin-2-yl)-7-oxo-5H,6H,7H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate, Zimovane,Zimovane LS, Hexal brand of zopiclone, (5S)-6-(5-chloropyridin-2-yl)-7-oxo-5H,6H,7H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate, Estorra,BPBio1_001146, 6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate,4-METHYL-1-PIPERAZINECARBOXYLIC ACID 6-(5-CHLORO-2-PYRIDINYL)-6,7-DIHYDRO-7-OXO-5H-PYRROLO(3,4-B)PYRAZIN-5-YL ESTER, Stadapharm brand of zopiclone,S-Zopiclone, Zopiclon AL, Gerard brand of zopiclone, Teva brand of zopiclone, Zopiclon-TEVA,ZOPICLONE [WHO-DD],AKOS005520380, Zopiclon-ratiopharm,Zopiclona,BCP28513,MLS000028547, SEP-190, Lunesta,4-Methyl-1-piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b] pyrazin-5-yl ester,zopiclone, Ratiopharm brand of zopiclone,Z 4900,zimovane,Zopiclonum,NSC 758463, AbZ brand of zopiclone, Ct-Arzneimittel brand of zopiclone,6-(5-CHLOROPYRID-2-YL)-5-(4-METHYLPIPERAZIN-1-YL)CARBONYLOXY-7-OXO-6,7-DIHYDRO-5H-PYRROLO(3,4-B)PYRAZINE,Zopiclone [INN:BAN:JAN],SCHEMBL44419,(+/-)-zopiclone, Neuraxpharm brand of zopiclone,NSC-758463,[6-(5-chloropyridin-2-yl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methylpiperazine-1-carboxylate,Zopiclone (1.0 mg/mL in Acetonitrile), 1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl ester, Rhodiapharm brand of zopiclone, Amovane,SR-01000000090-2, Ciclum brand of zopiclone,Biomol-NT_000284, Sopivan, Norton brand of zopiclone, (plus)-Zopiclone, Zopiclone (JAN/INN),Imovane, Zopiclonum, Hormosan brand of zopiclone,BRN 0768704,1169825-88-0,1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester,NSC758463, RP-27267, (+)-(5S)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methylpiperazine-1-carboxylate,Zopiclone, Rhone-Poulenc Rorer brand of zopiclone, Z 4900,SR-01000000090-7,SMR000048685,GTPL7430, (S)-Zopiclone,ZOPICLONE [MI],Zopiclone (TN), Eszopiclone (JAN/USAN/INN), Aventis Pharma brand of zopiclone,BRD-A34309505-001-10-1,SR-01000000090, Ratio-Zopiclone,MLS001201837, Amoban (TN),MFCD00133931,ZOPICLONE [EP MONOGRAPH], Azupharma brand of zopiclone,DEA No. 2784, 1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester,Q220426, Temmler brand of zopiclone, SEP-225441, Nu-Pharm brand of zopiclone,HMS3746I05, (5S)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methylpiperazine-1-carboxylate, 6-(5-chloro-2-pyridyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methyl-1-piperazinecarboxylate,EINECS 256-138-9,DTXSID4041155, Zopitan, Ran-zopiclone, Alpharma brand of zopiclone, SEP-0227018,Zopiclonum [INN-Latin],Zopiclona [INN-Spanish],Zileze 3.75, Aliud brand of zopiclone,W-106239, SEP-0227108, Pinewood brand of zopiclone,Esopiclone, Zopicalm, Zopiclon-neuraxpharm,43200-80-2,Amoban,Pharmakon1600-01503425, KS-1055, Zimoclone,CHEBI:32315

Categorías (no exhaustivas):

Substituted piperazine Substituted phenylmorpholine Substituted cathinone Methylphenidate analogue Aminorex analogue Imidazopyridine DOx Benzimidazole opioid Arylcyclohexylamine Xanthine Tryptamine Tropane Tricyclic Thiobarbiturate Cyclopyrrolone Pyrazolopyrimidine Substituted phenethylamine Lysergamide Diphenylbutylpiperidine Racetam Benzodiazepine Barbiturate Alkyl nitrite 25nb 2c Substituted amphetamine Naphthoylindole Phenylacetylindole Benzoylindole Cyclohexylphenol Check naphthoylpyrrole Naphthylmethylindene Tetramethylcyclopropanoylindoles Adamantoylindoles Indole3carboxylate ester Indazole3carboxamide Morphinan

Similitudes

Poder identificar moléculas similares a la que estudiamos puede permitir inferir algunas de sus propiedades. Hay varias formas de medir la similitud entre moléculas, por su estructura, efectos, interacciones farmacológicas, etc. A continuación, puedes encontrar moléculas similares según varios criterios y herramientas que desarrollamos. Para comprender las limitaciones de estas comparaciones, es crucial referirse siempre a la metodología utilizada para medir esas similitudes.Ten en cuenta: Esta información se proporciona únicamente con fines informativos y no debe interpretarse como asesoramiento médico.

Tipo de similitud

Para medir la similitud estructural, utilizamos el método de Mol2vec Mol2Vec, que es una red neuronal que procesa moléculas y las transforma en puntos en el espacio, de modo que las moléculas con subestructuras químicamente relacionadas se transforman en puntos cercanos en el espacio.

Estados legales

Para cada país, buscamos referencias y regulaciones relacionadas con esta molécula o con familias de compuestos a las que pertenece.

Descargo de responsabilidad: La información proporcionada en este sitio web sobre las referencias legales de las moléculas es solo con fines informativos y no constituye asesoramiento legal. Aunque nos esforzamos por mantener la información actualizada y precisa, las leyes y regulaciones pueden cambiar con el tiempo. Por lo tanto, no podemos garantizar la integridad, exactitud o aplicabilidad de la información proporcionada. Es importante consultar siempre los textos legales originales y hablar con un profesional legal calificado antes de tomar decisiones basadas en la información proporcionada en este sitio web.

Siempre verifica las fuentes proporcionadas, puede haber errores de clasificación. Nuestro sistema también puede haber omitido ciertas referencias.: Esta molécula se agregó en la legislación: Esta molécula se eliminó de la legislación

País:

Tipo de legislación

Narcotics

El sistema no ha detectado ninguna mención de esta molecula en France como Narcotics pero siempre debes verificarlo por ti mismo.

Psychotropes

2020-09-12

Molécula mencionada como "zopiclone"

Propiedades de la molécula

Utilizando el modelo de KGPT Aprendizaje Profundo, predecimos varias propiedades de la molécula. Las predicciones se agrupan según el conjunto de datos que se utilizó para obtener esas predicciones. Junto con cada predicción, proporcionamos un gráfico que muestra la distribución de los valores predichos en el conjunto de datos de entrenamiento/prueba/validación. Esto da una estimación de la confiabilidad del modelo.

Description: A dataset focused on predicting the inhibitory effects of molecules on the enzyme beta-secretase 1 (BACE1). BACE1 inhibition is a potential target for Alzheimer's disease treatment.

Class

TrainValTest

2.88-3.70-1.36

Description: A dataset providing insights on the ability of molecules to penetrate the blood-brain barrier. Crucial for understanding the potential of molecules as central nervous system drugs.

p_np

TrainValTest

-2.24-3.290.40

Description: This dataset deals with the FDA approval status and clinical trial toxicity of molecules. Important for understanding the safety and regulatory status of compounds.

CT_TOX

TrainValTest

-0.49-0.78-0.91

FDA_APPROVED

TrainValTest

0.53-1.27-0.50

Description: A dataset that predicts the solubility of molecules in water. Solubility is an essential property influencing bioavailability and the potential formulation of a drug.

logSolubilitylog(mol/L)

-0.75

TrainValTest

Description: This dataset is centered on predicting the free energy when a molecule is dissolved in water. The energy changes can affect molecular interactions in biological systems.

freesolvkcal/mol

-2.42

TrainValTest

Description: A dataset predicting the lipophilicity of molecules. Lipophilicity is a crucial factor affecting the distribution, metabolism, and excretion of drugs in the body.

lipoAlogP

-0.94

TrainValTest

Description: This dataset gives insights into the metabolic stability of molecules. High metabolic stability often results in a longer half-life, influencing drug dosage and frequency.

low

TrainValTest

-0.17-3.50-2.88

high

TrainValTest

0.72-3.55-0.49

27 entries

12 entries

617 entries

Interacción de esta molécula con el metabolismo

Utilizamos un modelo de Aprendizaje Profundo para predecir las interacciones de esta molécula con el metabolismo. Consulta la fuente para entender la metodología.

Reacciones que metabolizan esta molécula

Hydrolysis of cyclic tertiary carboxamide BTMR0094

Enzimas: EC 3.5.2.X

Reagents

Metabolite: InChI=1S/C17H19...

Pyridine N-oxidation BTMR0096

Enzimas: CYP1A2 CYP2C9 CYP2D6 CYP3A4

Reagents

Metabolite: InChI=1S/C17H17...

N-Oxidation of alicyclic tertiary amine BTMR1099

Enzimas: CYP1A2 CYP2C8 CYP2C19 CYP2D6 CYP3A4

Reagents

InChI=1S/C17H17ClN6O...

N-Dealkylation of alicyclic tertiary amine BTMR1144

Enzimas: CYP1A2 CYP2A6 CYP2B6 CYP2C8 CYP2C9 CYP2C19 CYP2D6 CYP3A4

Reagents

InChI=1S/C16H15ClN6O...

Hydroxylation of heteroalicyclic secondary carbon BTMR1070

Enzimas: CYP1A2 CYP2A6 CYP2C9 CYP2D6 CYP3A4

Reagents

Metabolite: InChI=1S/C17H17...

Hydroxylation of heteroalicyclic secondary carbon BTMR1070

Enzimas: CYP1A2 CYP2A6 CYP2C9 CYP2D6 CYP3A4

Reagents

Metabolite: InChI=1S/C17H17...

Hydroxylation of aromatic carbon ortho to halide group BTMR1040

Enzimas: CYP1A2 CYP2A6 CYP2B6 CYP2C8 CYP2C9 CYP2C19 CYP2D6 CYP2E1 CYP3A4

Reagents

Metabolite: InChI=1S/C17H17...

Hydroxylation of aromatic carbon ortho to halide group BTMR1040

Enzimas: CYP1A2 CYP2A6 CYP2B6 CYP2C8 CYP2C9 CYP2C19 CYP2D6 CYP2E1 CYP3A4

Reagents

Metabolite: InChI=1S/C17H17...

Hydroxylation of aromatic carbon meta to halide group BTMR1039

Enzimas: CYP2A6 CYP2B6 CYP2C9 CYP2C19 CYP2E1 CYP3A4

Reagents

Zopiclone

eszopiclone

zopiclone

Zopiclone

Zopiclone

Eszopiclone

Zopiclone

Eszopiclone

Eszopiclone

Zopiclone

Eszopiclone

Similitudes

Estados legales

Propiedades de la molécula

Perspectivas avanzadas

Interacción de esta molécula con el metabolismo

Metabolite: InChI=1S/C17H19...

Metabolite: InChI=1S/C17H17...

InChI=1S/C17H17ClN6O...

InChI=1S/C16H15ClN6O...

Metabolite: InChI=1S/C17H17...

Metabolite: InChI=1S/C17H17...

Metabolite: InChI=1S/C17H17...

Metabolite: InChI=1S/C17H17...

Metabolite: InChI=1S/C17H17...