WHC is still in active development. Read this to understand our approach.
depiction of ADEBPBSSDYVVLD-UHFFFAOYSA-N.svg
isomerdesign

Donepezil

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pubchem

Donepezil

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drugmap

Donepezil

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Donepezil

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Data

InChI: InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3

Synonyms: 2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one,Donepezil,DONEPEZIL [MI],KBio2_004712,SCHEMBL2149,5,6-DIMETHOXY-2-((1-(PHENYLMETHYL)-4-PIPERIDINYL)METHYL)-2,3-DIHYDRO-1H-INDEN-1-ONE,KBio2_002144,2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one,Domepezil,KBio2_007280,AB00640013-08,2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inden-1-one,2-((1-benzyl-4-piperidyl)methyl)-5,6-dimethoxy-2,3-dihydroinden-1-one,DONEPEZIL [HSDB],Q415081,5,6-dimethoxy-2-[[1-(phenylmethyl)piperidin-4-yl]methyl]-2,3-dihydroinden-1-one,DONEPEZIL [INN],AMY8939,CHEBI:145499,2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one,AKOS000277311,(+/-)-2-((1-BENZYL-4-PIPERIDYL)METHYL)-5,6-DIMETHOXY-1-INDANONE,DONEPEZIL [VANDF],SCHEMBL8265876,Donepezil [INN:BAN],BDBM8960,AB00640013_09,BCP9000622,NCGC00167537-01,014D064,(RS)-2-[(1-BENZYL-4-PIPERIDYL)METHYL]-5,6-DIMETHOXYINDAN-1-ONE,CHEBI:53289,Z1741977105,2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one,Oprea1_188452,8SSC91326P,DONEPEZIL [WHO-DD],120014-06-4,142057-79-2,CHEMBL502,D-797,AB00640013-07,NSC 758882,UNII-8SSC91326P,2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one,BRD-A49160188-003-04-4,(+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-indan-1-one,Donepezil (INN),HSDB 7743,AKOS016842349,1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-,BCPP000253,donepezilum,AC-6969,Donepezil (transdermal patch, Alzheimer's disease),CCG-268401,142057-80-5,KBioSS_002144,STK003905,D797,DB00843,AB00640013_10,Spectrum5_001662,Spectrum_001664,DONEPEZIL [JAN],Aricept,2,3-dihydro-5,6-dimethoxy-2[[1-(phenyl methyl)-4-piperidinyl]methyl]-1H-inden-1-one,EN300-267872,donepezilo,1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-,NSC 737535,D07869,HY-14566,s5073,(S)-E2020 (free base),2,3-dihydro-5,6-dimethoxy-2 [[1-(phenyl methyl)-4-piperidinyl]methyl]-1H-inden-1-one,Q-100098,GTPL6599,2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1h-inden-1-one,Donaz,2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one,FT-0601545,SBI-0206789.P001,2-[(1-benzyl-4-piperidyl)methyl]- 5,6-dimethoxy-2,3-dihydroinden-1-one,BCP07590,donepezil,MRF-0000323,HMS3886M11,Donaz (TN),MFCD00912833,DTXSID8048317

Estimated data

Solubility: -4.753 (log(S) in mol/L prediction using SolTranNet)

Blood Brain Barrier Permeability: Yes (prediction using frontiersin.org)

Addictivity Prediction: 32.6% (prediction based on www.mdpi.com)

Similarities

The following is a set of comparisons to understand the properties of this compound. This is still higly experimental and is still under active development. Please refer to our series of blog posts to fully understand our approach and its limitations. This information is for informational purposes only and should not be construed as medical advice.