PMA

Check on isomerdesign

4-Methoxyamphetamine

Check on pubchem

Beta-methoxyamphetamine

Check on drugmap

Para-Methoxyamphetamine

Check on wiki

SMILES:COC1=CC=C(CC(C)N)C=C1

InChI:InChI=1S/C10H15NO/c1-8(11)7-9-3-5-10(12-2)6-4-9/h3-6,8H,7,11H2,1-2H3

InChI key:NEGYEDYHPHMHGK-UHFFFAOYSA-N

Synonyms:

(+-)-p-Methoxyamphetamine, 23239-32-9, 1-p-Methoxyphenyl-2-propylamine, DL-p-Methoxy-alpha-methylphenethylamine, paramethoxyamphetamine, beta-methoxyamphetamine,4-Methoxyamphetamine,1-(4-Methoxyphenyl)propan-2-amine, DEA No 7411, NSC 32757,PMA, 1-(4-methoxyphenyl)propan-2-amine,4-MA, (+-)-p-Methoxy-alpha-methylphenethylamine, 64-13-1, 1-(4-Methoxybenzyl)ethylamine, p-Methoxyamphetamine, 1-p-Methoxyphenyl-2-aminopropane, Para-Methoxyamphetamine,4-MeO-AMP, para-methoxyamphetamine, p-Methoxy-alpha-methylphenethylamine, 50505-80-1, 2-Amino-1-(4'-methoxyphenyl)propane

Categories (non-exhaustive):

Substituted piperazine Substituted phenylmorpholine Substituted cathinone Methylphenidate analogue Aminorex analogue Imidazopyridine DOx Benzimidazole opioid Arylcyclohexylamine Xanthine Tryptamine Tropane Tricyclic Thiobarbiturate Cyclopyrrolone Pyrazolopyrimidine Substituted phenethylamine Lysergamide Diphenylbutylpiperidine Racetam Benzodiazepine Barbiturate Alkyl nitrite 25nb 2c Substituted amphetamine Naphthoylindole Phenylacetylindole Benzoylindole Cyclohexylphenol Check naphthoylpyrrole Naphthylmethylindene Tetramethylcyclopropanoylindoles Adamantoylindoles Indole3carboxylate ester Indazole3carboxamide Morphinan

Similarities

Being able to identify molecules that are similar to the one we study can allow to infer some of its properties. There are several ways of measuring the similarity between molecules, by their structure, effects, pharmacological interactions etc. In the following, you can find similar molecules according to various criterions and tools that we developed. To understand the limitations of these comparisons, it is crucial to always refer to the methodology that was used to measure those similarities. Please note: This information is provided solely for informational purposes and should not be interpreted as medical advice.

Similarity type

To measure structural similarity, we use the Mol2vec method, which is a neural network that processes molecules and transform them into points in spaces, such that molecules with chemically related substructures are transformed into points that are close in space.

Legal statuses

For each country, we look for references and regulations related to this molecule, of to families of compounds that this molecule belongs to.

Disclaimer: The information provided on this website regarding the legal references of molecules is for informational purposes only and does not constitute legal advice. While we strive to keep the information up-to-date and accurate, laws and regulations may change over time. Therefore, we cannot guarantee the completeness, accuracy, or applicability of the information provided. It is important to always refer to the original legal texts and consult with a qualified legal professional before making any decisions based on the information provided on this website.

Always double check the sources provided, there can be classification errors. Our system may also have missed certain references. : This molecule was added in the legislation: This molecule was removed from the legislation

Country:

Type of legislation

Narcotics

2021-05-23

Molecule mentionned as "phénéthylamines et des alpha-méthylphénéthylamines"

Psychotropes

The system hasn't detected any mention of this drug in France as a Psychotropes but you should always double check by yourself.

Molecule properties

Using the KGPT Deep Learning model, we predict several property of the molecule. Predictions are grouped by the dataset that was used to get those prediction. Along with each prediction, we provide a plot that shows the distribution of predicted values on the train/test/val dataset. This gives an estimate of the reliability of the model.

Description: A dataset focused on predicting the inhibitory effects of molecules on the enzyme beta-secretase 1 (BACE1). BACE1 inhibition is a potential target for Alzheimer's disease treatment.

Class

TrainValTest

2.88-3.70-1.36

Description: A dataset providing insights on the ability of molecules to penetrate the blood-brain barrier. Crucial for understanding the potential of molecules as central nervous system drugs.

p_np

TrainValTest

-2.24-3.290.40

Description: This dataset deals with the FDA approval status and clinical trial toxicity of molecules. Important for understanding the safety and regulatory status of compounds.

CT_TOX

TrainValTest

-0.49-0.78-0.91

FDA_APPROVED

TrainValTest

0.53-1.27-0.50

Description: A dataset that predicts the solubility of molecules in water. Solubility is an essential property influencing bioavailability and the potential formulation of a drug.

logSolubilitylog(mol/L)

0.57

TrainValTest

Description: This dataset is centered on predicting the free energy when a molecule is dissolved in water. The energy changes can affect molecular interactions in biological systems.

freesolvkcal/mol

-0.99

TrainValTest

Description: A dataset predicting the lipophilicity of molecules. Lipophilicity is a crucial factor affecting the distribution, metabolism, and excretion of drugs in the body.

lipoAlogP

-2.24

TrainValTest

Description: This dataset gives insights into the metabolic stability of molecules. High metabolic stability often results in a longer half-life, influencing drug dosage and frequency.

low

TrainValTest

-0.17-3.50-2.88

high

TrainValTest

0.72-3.55-0.49

27 entries

12 entries

617 entries

Affinities

Binding affinities with a list of 61 predefined docking sites. Those affinities are used to compute the interactions similarities.

Interaction of this molecule with metabolism

We use a Deep Learning model to predict the interactions of this molecule with metabolism. Refer to the source to understand the methodology.

Reactions that metabolize this molecule

Hydroxylation of non-terminal aliphatic carbon adjacent to aromatic ring BTMR1077

Enzymes: CYP1A2 CYP2C8 CYP2C9 CYP2D6 CYP3A4

Reagents

β-HO-PMA

O-Dealkylation BTMR0052

Enzymes: CYP1A2 CYP2A6 CYP2C9 CYP2C19 CYP2D6 CYP2E1 CYP3A4

Reagents

PHA

Hydroxyamphetamine

4-Hydroxyamphetamine

2-Hydroxylation of 1,4-disubstituted benzene BTMR0037

Enzymes: CYP1A2

Reagents

HMA

Hydroxylation of terminal methyl BTMR1061

Enzymes: CYP1A2 CYP2A6 CYP2B6 CYP2C8 CYP2C9 CYP2C19 CYP2D6 CYP2E1 CYP3A4

Reagents

InChI=1S/C10H15NO2/c...

Terminal desaturation BTMR1190

Enzymes: CYP1A2 CYP2A6 CYP2C9 CYP2D6 CYP3A4

Reagents

Metabolite: InChI=1S/C10H13...

Reactions that metabolism produce from this molecule

N-Dealkylation of acyclic secondary amine BTMR1140

Enzymes: CYP1A2 CYP2B6 CYP2C8 CYP2C9 CYP2C19 CYP2D6 CYP3A4

Products

N-Pr-PMA

N-Dealkylation of acyclic secondary amine BTMR1140

Enzymes: CYP1A2 CYP2B6 CYP2C8 CYP2C9 CYP2C19 CYP2D6 CYP3A4

Products

N-Et-PMA

Para-Methoxy-N-ethylamphetamine

N-Dealkylation of acyclic secondary amine BTMR1140

Enzymes: CYP1A2 CYP2B6 CYP2C8 CYP2C9 CYP2C19 CYP2D6 CYP3A4

Products

Arformoterol

(S,S)-Formoterol

Formoterol

Arformoterol

Formoterol

Arformoterol

Methylation of phenolic compound BTMR1377

Enzymes: 2.1.1.25

Products

PHA

Hydroxyamphetamine

4-Hydroxyamphetamine

N-Dealkylation of acyclic secondary amine BTMR1140

Enzymes: CYP1A2 CYP2B6 CYP2C8 CYP2C9 CYP2C19 CYP2D6 CYP3A4

Products

PMMA

4-MeO-MA

Para-Methoxy-N-methylamphetamine

3'-Dehydroxylation of substituted benzene BTMR1314

Enzymes: Unspecified bacterial dehydroxylase

Products

HMA

N-Deisopropylation BTMR0051

Enzymes: CYP1A2 CYP2B6 CYP2C8 CYP2C9 CYP2C19 CYP2E1 CYP3A4

Products

N-iPr-PMA

N-Dealkylation of acyclic secondary amine BTMR1140

Enzymes: CYP1A2 CYP2B6 CYP2C8 CYP2C9 CYP2C19 CYP2D6 CYP3A4

Products

Metabolite: InChI=1S/C13H21...

N-Dealkylation of acyclic secondary amine BTMR1140

Enzymes: CYP1A2 CYP2B6 CYP2C8 CYP2C9 CYP2C19 CYP2D6 CYP3A4

Products

PMA

PMA

4-Methoxyamphetamine

Beta-methoxyamphetamine

Para-Methoxyamphetamine

Similarities

Legal statuses

Molecule properties

Advanced insights

Affinities

Interaction of this molecule with metabolism

β-HO-PMA

PHA

Hydroxyamphetamine

4-Hydroxyamphetamine

HMA

InChI=1S/C10H15NO2/c...

Metabolite: InChI=1S/C10H13...

N-Pr-PMA

N-Et-PMA

Para-Methoxy-N-ethylamphetamine

Arformoterol

(S,S)-Formoterol

Formoterol

Arformoterol

Formoterol

Arformoterol

PHA

Hydroxyamphetamine

4-Hydroxyamphetamine

PMMA

4-MeO-MA

Para-Methoxy-N-methylamphetamine

HMA

N-iPr-PMA

Metabolite: InChI=1S/C13H21...

N-[1-(4-Methoxyphenyl)propan-2-yl]-3-phenylpropan-1-amine