Lorazepam

tripsit

lorazepam

Check on tripsit

psychonaut

Lorazepam

Check on psychonaut

isomerdesign

Lorazepam

Check on isomerdesign

druglab

Lorazépam

Check on druglab

drugmap

Lorazepam

Check on drugmap

wiki

Lorazepam

Check on wiki

SMILES:OC1=NC2=C(C=C(Cl)C=C2)C(C2=CC=CC=C2Cl)=NC1O

InChI:InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)

InChI key:DIWRORZWFLOCLC-UHFFFAOYSA-N

Synonyms: Lorazin, Llorens Brand of Lorazepam,Anxiedin,Lorazepam (JP17/USP/INN), Lorazep,Tox21_111669,Laubeel, Lorzem, Temesta (TN), Sedatival,SMR000058410, Duralozam,Loraz, Novo Lorazem,Loridem,LORAZEPAM [EP MONOGRAPH],Wypax,7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one.,Orfidal, Aplacassee,7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one,Lorazepam 1.0 mg/ml in Acetonitrile, Lorat, Lorazepamum [INN-Latin], Lorsedal,Demethyllormetazepam, Bonton, Vigiten, Desitin Brand of Lorazepam,NSC-289758,Lorazepam, United States Pharmacopeia (USP) Reference Standard,Lorazepam Lannacher,BRD-A11990600-001-01-8,Lorazon,NC00420, AHP Brand of Lorazepam,Rocosgen, Ativan (TN), Serra Pamies Brand of Lorazepam,Nervistop L, Lorapam,DEA No. 2885,Novolorazem,Azurogen, Securit, Lorazepam-Efeka, Sedazin, Lorazepam Medix Brand, Lorazepam Genericon,Lorivan,Sidenar, Pro dorm, 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one, Lorazepam Dolorgiet Brand,7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one,Wy-4036,(+/-)-Lorazepam, Kalmalin, Quait,7-chloro-3-hydroxy-5-(2'-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one, Orfidal Wyeth,Lozepam,7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one,Lorazepam solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Lorazepam neuraxpharm Brand, Lorazepam neuraxpharm,Ativan, O-Chloroxazepam, Norlormetazepam,CCG-101170,Delormetazepam,Lorazepam for system suitability, European Pharmacopoeia (EP) Reference Standard,Vigiten, Lorazon, Lorazepam Llorens Brand, Lorafen,Emotion,WLN: T67 GMV JN IHJ CG IQ KR BG, Lorazin,BDBM50292627,LORAZEPAM [VANDF], Renaquil,2H-1, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-, Max Pax, Lopam,DTXSID7023225, Bonatranquan,Equitam,CAS-846-49-1,Lorazene, Lorazepam Medical Brand,Lorabenz, 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one, Lorazepam Novopharm Brand, Baxter Brand of Lorazepam,Efasedan, Loridem,Lorazepam Genericon,Lorazepan Chobet, Apo Lorazepam,Lorazepam 0.1 mg/ml in Acetonitrile,HMS2052H07, Merlit, Aplacasse,Securit, Loraz, Delormetazepam,LORAZEPAM [MART.], Lorazepam Lannacher,Loram,HMS503A11, Lomesta, Demethyllormetazepam,LORAZEPAM [WHO-DD],Larpose, Nu-Loraz,lorazepam,LORAZEPAM [ORANGE BOOK], Efasedan, 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one,7-chloro-3-hydroxy-5-(2'-chloro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one, 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one, Ct Arzneimittel Brand of Lorazepam,Upan, Sedizepan, Laubeel,5-25-02-00248 (Beilstein Handbook Reference),7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one (lorazepam), Lorazepam Baxter Brand, Wyeth Brand of Lorazepam,7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one,LORAZEPAM7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one,Tolid,(RS)-9-chloro-6-(2-chlorophenyl)-4-hydroxy-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one,ativan,Sedatival, Lorazepam-neuraxpharm,(+-)-7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one, L1764_SIGMA, Lorabenz, O-Chlorooxazepam, Somagerol, Stapam,2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-,7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one #, Apotex Brand of Lorazepam, Anzepam,Anzepam, Lorazepan Chobet,Lorazepam preservative free,D00365,Punktyl, Azurogen, Rocosgen, Nu-Pharm Brand of Lorazepam, Temesta,NSC289758,HMS3394H07, Lorsilan, Lorazepam Fabra,Lorazepam civ, Emotion,LORAZEPAM [MI],Lorazep, Durazolam, Lorazepam Riemser Brand, Merck dura Brand of Lorazepam, Lorazepam Apotex Brand, Upan,Lorsedal,Lorazepamum,CHEBI:6539,NSC 289758,2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, (+-)-, Punktyl,O-Chloroxazepam; O-Chlorooxazepam; Almazine; WY 4036; WY-4036; WY4036,DB00186, Larpose,EINECS 212-687-6, Lorazepam ratiopharm, Lorazepam Wyeth Brand,LORAZEPAM [EP IMPURITY],AKOS015904303, Lorazepam ratiopharm Brand, WY4036,DSSTox_GSID_23225,Stapam,Tavor,Sedazin,(+/-)-7-CHLORO-5-(O-CHLOROPHENYL)-1,3-DIHYDRO-3-HYDROXY-2H-1,4-BENZODIAZEPIN-2-ONE,Lorazepam Fabra,SCHEMBL26961,Lorazepam Intensol,CHEMBL580, ApoLorazepam,Kalmalin,Lorazepan Richet, Trapax, Lorazepamum, Donix,2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-,Max Pax,Emotival, Tranqipam,DSSTox_RID_76932, Lorazepam Desitin Brand, Lorazepam AHP Brand,Nervistopl,Tranqipam, Lorazepam-ratiopharm,Aripax, Lorazene, Ativan, Orfidal,846-49-1,Duralozam, Emotival,Anxira,Merlit,2H-1, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-,Lorenin, Nu Pharm Brand of Lorazepam, Novopharm Brand of Lorazepam,UNII-O26FZP769L,Apo-Lorazepam, Wy-4036, Riemser Brand of Lorazepam,LORAZEPAM CIV [USP-RS], Lorazepam Medical,NCGC00159439-02,LOREEV XR, Lorazepam (Ativan),MLS001424236,Trapax, Equitam,o-Chloroxazepam,LORAZEPAM [USP MONOGRAPH], Lorax,Lorazepam, British Pharmacopoeia (BP) Reference Standard, Lorazepam Intensol, Silence,Temesta,BRN 0759084, Ratiopharm Brand of Lorazepam,L-230, Dolorgiet Brand of Lorazepam, Novhepar,Lorax,Silence,Lorat,846L491, Sidenar, Sedicepan, Tavor,KBio1_000965, Novartis Brand of Lorazepam, Loram, Lorazepam (JP15/USP/INN),A840886,2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-5-(2-CHLOROPHENYL)-1,3-DIHYDRO-3-HYDROXY-, (+/-)-, Novolorazem,Lopam,DivK1c_000965,DTXCID303225,Idalprem,Lorazepam Medical, Neuraxpharm Brand of Lorazepam,Pro dorm, Ct-Arzneimittel Brand of Lorazepam, Lorazepam Novartis Brand,7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one,BCP13713,7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one, Lorivan, Sinestron,Bonton, Nervistop L, Anxira,Donix, Tolid,Lorapam,Lorsilan,O26FZP769L,Wy 4036, (+/-)-Lorazepam, Lorenin, Nervistopl, 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one,Lomesta,Somagerol,Novhepar,o-Chlorooxazepam,IDI1_000965,7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-benzo[e][1,4]diazepin-2(3H)-one, Apo-Lorazepam, Lozepam,Aplacasse,DSSTox_CID_3225, Nu Loraz,Lorazepam,Lorazepam [USAN:USP:INN:BAN:JAN],Aplacassee, Medical Brand of Lorazepam,GTPL5884, Wypax,Renaquil,Lorazepamum [INN-Latin], Lorazepam preservative free,Nu Loraz,Q408265,Norlormetazepam,Sinestron, Lorazepam [USAN:INN:BAN:JAN],Sedizepan, Idalprem, Lorazepan Richet, Lorazepam ct-Arzneimittel Brand, Medix Brand of Lorazepam,Ativan (TN),LORAZEPAM [USAN],Lorans, Novo-Lorazem,LORAZEPAM [INN], Wy 4036, Medical, Lorazepam, Wyeth, Orfidal, NuLoraz,7-Chloro-5-(o-chlorophenyl)-1,4-benzodiazepin-2-one,Quait,7-chloro-5-(2-chlorophenyl)-3-hydroxy-2,3-dihydro-1H-1,4-benzodiazepin-2-one,(.+/-.)-Lorazepam, Anxiedin,Almazine,7-chloranyl-5-(2-chlorophenyl)-3-oxidanyl-1,3-dihydro-1,4-benzodiazepin-2-one,7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one, Lorazep von ct, (+-)-7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one,Lorazepam-Efeka, Lorans, Aripax, Lorazepam Nu-Pharm Brand,LORAZEPAM [JAN],Lorazepam, European Pharmacopoeia (EP) Reference Standard, Alzapam,Bonatranquan,NINDS_000965,Lorafen,Lorzem

Similarities

Being able to identify molecules that are similar to the one we study can allow to infer some of its properties. There are several ways of measuring the similarity between molecules, by their structure, effects, pharmacological interactions etc. In the following, you can find similar molecules according to various criterions and tools that we developed. To understand the limitations of these comparisons, it is crucial to always refer to the methodology that was used to measure those similarities. Please note: This information is provided solely for informational purposes and should not be interpreted as medical advice.

To measure structural similarity, we use the Mol2vec method, which is a neural network that processes molecules and transform them into points in spaces, such that molecules with chemically related substructures are transformed into points that are close in space.

Molecule properties

Using the KGPT Deep Learning model, we predict several property of the molecule. Predictions are grouped by the dataset that was used to get those prediction. Along with each prediction, we provide a plot that shows the distribution of predicted values on the train/test/val dataset. This gives an estimate of the reliability of the model.

Description: A dataset focused on predicting the inhibitory effects of molecules on the enzyme beta-secretase 1 (BACE1). BACE1 inhibition is a potential target for Alzheimer's disease treatment.
Class
TrainValTest
2.88-3.70-1.36
Description: A dataset providing insights on the ability of molecules to penetrate the blood-brain barrier. Crucial for understanding the potential of molecules as central nervous system drugs.
p_np
TrainValTest
-2.24-3.290.40
Description: This dataset deals with the FDA approval status and clinical trial toxicity of molecules. Important for understanding the safety and regulatory status of compounds.
CT_TOX
TrainValTest
-0.49-0.78-0.91
FDA_APPROVED
TrainValTest
0.53-1.27-0.50
Description: A dataset that predicts the solubility of molecules in water. Solubility is an essential property influencing bioavailability and the potential formulation of a drug.
logSolubilitylog(mol/L)
-0.79
TrainValTest
Description: This dataset is centered on predicting the free energy when a molecule is dissolved in water. The energy changes can affect molecular interactions in biological systems.
freesolvkcal/mol
-2.58
TrainValTest
Description: A dataset predicting the lipophilicity of molecules. Lipophilicity is a crucial factor affecting the distribution, metabolism, and excretion of drugs in the body.
lipoAlogP
0.09
TrainValTest
Description: This dataset gives insights into the metabolic stability of molecules. High metabolic stability often results in a longer half-life, influencing drug dosage and frequency.
low
TrainValTest
-0.17-3.50-2.88
high
TrainValTest
0.72-3.55-0.49
27 entries
12 entries
617 entries

Advanced insights

In the following we provide more advanced analysis about the interactions of a molecule with the human metabolism, docking sites etc.

Interaction of this molecule with metabolism

We use a Deep Learning model to predict the interactions of this molecule with metabolism. Refer to the source to understand the methodology.

Reactions that metabolize this molecule
Aromatic hydroxylation of fused benzene ring BTMR1030
Reagents

Metabolite: InChI=1S/C15H10...

Hydroxylation of benzene on carbon ortho to electron donating group BTMR1045
Reagents

Metabolite: InChI=1S/C15H10...

Hydroxylation of aromatic carbon para to halide group BTMR1041
Enzymes: CYP1A2 CYP2E1 CYP3A4
Reagents

Metabolite: InChI=1S/C15H10...

Hydroxylation of benzene on carbon para to electron donating group BTMR1047
Reagents

Metabolite: InChI=1S/C15H10...

Aromatic hydroxylation of fused benzene ring BTMR1031
Reagents

Metabolite: InChI=1S/C15H10...

Aromatic hydroxylation of fused benzene ring BTMR1032
Reagents

Metabolite: InChI=1S/C15H10...

Hydroxylation of aromatic carbon ortho to halide group BTMR1040
Reagents

Metabolite: InChI=1S/C15H10...

Hydroxylation of aromatic carbon ortho to halide group BTMR1040
Reagents

Metabolite: InChI=1S/C15H10...

Hydroxylation of aromatic carbon ortho to halide group BTMR1040
Reagents

Metabolite: InChI=1S/C15H10...

Reactions that metabolism produce from this molecule
N-Dealkylation of tertiary carboxamide BTMR1139
Hydroxylation of heteroalicyclic secondary carbon BTMR1070